Marchf6 | membrane associated ring-CH-type finger 6

GeneMGI:2442773Synonyms: March6, F830029L24Rik

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Limbs/digits/tail Nervous system Respiratory system Hematopoietic system Behavior/neurological Skeleton Craniofacial

9 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

2Associated diseases

Expression examined in:78Adult tissues

36Embryo tissues

Phenotypes

Phy. System:



decreased grip strength	2 supporting datasets	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.8x10^-6
decreased prepulse inhibition	4 supporting datasets	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.62x10^-8
increased fasting circulating glucose level	1 supporting dataset	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.4x10^-13
short tibia	2 supporting datasets	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.91x10^-6
decreased exploration in new environment	3 supporting datasets	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.15x10^-17
decreased airway resistance	2 supporting datasets	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.67x10^-45
decreased body weight	2 supporting datasets	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.22x10^-8
small testis	1 supporting dataset	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.88x10^-5
thrombocytopenia	1 supporting dataset	Marchf6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.27x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Marchf6.

Associated images

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Histopathology

There is no histopathology data found for Marchf6.

IMPC related publications

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External links

No external links available for Marchf6.

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*Marchf6^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Marchf6^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Marchf6^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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