Rfx7 | regulatory factor X, 7

GeneMGI:2442675Synonyms: 2510005N23Rik, D130086K05Rik, +2 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

abnormal retina morphology1 supporting datasetRfx7tm2b(EUCOMM)HmguheterozygoteEarly adult4.56x10-9 
decreased fasting circulating glucose level1 supporting datasetRfx7tm2b(EUCOMM)HmguheterozygoteEarly adult5.49x10-5 
decreased locomotor activity1 supporting datasetRfx7tm2b(EUCOMM)HmguheterozygoteEarly adult7.8x10-5 
decreased thigmotaxis1 supporting datasetRfx7tm2b(EUCOMM)HmguheterozygoteEarly adult4.94x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetRfx7tm2b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rfx7tm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Rfx7tm2b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Rfx7tm2c(EUCOMM)HmguWild type floxed exon (post-Flp)mouse
Rfx7tm2e(EUCOMM)HmguTargeted, non-conditional allelees cell

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