Naa25 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit

GeneMGI:2442563Synonyms: 4833422K13Rik, C330023M02Rik

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Integument Hematopoietic system Behavior/neurological Skeleton Mortality/aging

13 No significant impact

3 Not tested

Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

embryonic lethality prior to organogenesis1 supporting datasetNaa25em1(IMPC)TcphomozygoteE9.5N/A * 
preweaning lethality, complete penetrance3 supporting datasetsNaa25em1(IMPC)TcphomozygoteEarly adultN/A * 
prenatal lethality prior to heart atrial septation1 supporting datasetNaa25em1(IMPC)TcphomozygoteE15.5N/A * 
hyperactivity1 supporting datasetNaa25em1(IMPC)TcpheterozygoteEarly adult8.68x10-5 
enlarged lymph nodes1 supporting datasetNaa25em1(IMPC)TcpheterozygoteLate adultN/A * 
enlarged thymus1 supporting datasetNaa25em1(IMPC)TcpheterozygoteLate adultN/A * 
abnormal skin morphology1 supporting datasetNaa25em1(IMPC)TcpheterozygoteLate adultN/A * 
abnormal uterus morphology1 supporting datasetNaa25em1(IMPC)TcpheterozygoteLate adultN/A * 
abnormal skin morphology1 supporting datasetNaa25em1(IMPC)TcpheterozygoteEarly adultN/A * 
abnormal sternum morphology1 supporting datasetNaa25em1(IMPC)TcpheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Naa25em1(IMPC)TcpExon Deletionmouse
Naa25tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Naa25tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell

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