Frmd5 | FERM domain containing 5

GeneMGI:2442557Synonyms: 1500032A09Rik, A930004K21Rik

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Pigmentation Adipose tissue Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



hyperactivity	1 supporting dataset	Frmd5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.47x10^-5
decreased grip strength	2 supporting datasets	Frmd5^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.05x10^-5
decreased prepulse inhibition	5 supporting datasets	Frmd5^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.53x10^-8
abnormal eye morphology	1 supporting dataset	Frmd5^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.11x10^-5
abnormal lens morphology	1 supporting dataset	Frmd5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.58x10^-6
increased total body fat amount	1 supporting dataset	Frmd5^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.08x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Frmd5^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased lean body mass	1 supporting dataset	Frmd5^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.61x10^-5
female infertility	1 supporting dataset	Frmd5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal retina pigmentation	2 supporting datasets	Frmd5^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.9x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Frmd5.

Associated images

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Histopathology

There is no histopathology data found for Frmd5.

IMPC related publications

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External links

No external links available for Frmd5.

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*Frmd5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Frmd5^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Frmd5^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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