Arhgef4 | Rho guanine nucleotide exchange factor 4

GeneMGI:2442507Synonyms: Asef, C230030N03Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:28Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating HDL cholesterol level	1 supporting dataset	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.3x10^-7
increased bone mineral content	1 supporting dataset	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	8.04x10^-8
increased body length	1 supporting dataset	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.96x10^-5
abnormal response to tactile stimuli	1 supporting dataset	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.2x10^-7
decreased body weight	1 supporting dataset	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.11x10^-7
increased lean body mass	2 supporting datasets	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.85x10^-11
abnormal behavior	3 supporting datasets	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.6x10^-8
decreased circulating triglyceride level	1 supporting dataset	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.39x10^-12
decreased circulating free fatty acids level	1 supporting dataset	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.65x10^-5
decreased T cell number	1 supporting dataset	Arhgef4^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.32x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arhgef4.

Associated images

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Histopathology

There is no histopathology data found for Arhgef4.

IMPC related publications

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External links

No external links available for Arhgef4.

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*Arhgef4^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Arhgef4^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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