Gak | cyclin G associated kinase

GeneMGI:2442153Synonyms: D130045N16Rik

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Integument Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system Renal/urinary system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal heart morphology	1 supporting dataset	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased circulating potassium level	1 supporting dataset	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	1.12x10^-5
enlarged spleen	2 supporting datasets	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.74x10^-15
abnormal spleen morphology	2 supporting datasets	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged kidney	1 supporting dataset	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
increased kidney weight	1 supporting dataset	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	6.33x10^-6
enlarged thymus	1 supporting dataset	Gak^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gak.

Associated images

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Histopathology

There is no histopathology data found for Gak.

IMPC related publications

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External links

No external links available for Gak.

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*Gak^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Gak^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gak^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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