Lpp | LIM domain containing preferred translocation partner in lipoma

GeneMGI:2441849Synonyms: B130055L10Rik, 9430020K16Rik

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Nervous system Vision/eye Liver/biliary system Cardiovascular system Mortality/aging

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:78Adult tissues

35Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal liver morphology	2 supporting datasets	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Late adult	N/A ^*
abnormal retina blood vessel morphology	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.76x10^-8
persistence of hyaloid vascular system	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.45x10^-6
abnormal retina vasculature morphology	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.91x10^-7
abnormal body fat mass	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Late adult	1.11x10^-7
abnormal retina morphology	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.23x10^-6
increased circulating phosphate level	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.01x10^-7
preweaning lethality, incomplete penetrance	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal optic disk morphology	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.09x10^-7
abnormal lean body mass	1 supporting dataset	Lpp^{tm1b(KOMP)Wtsi}	homozygote	Late adult	7.16x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lpp.

Associated images

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Histopathology

There is no histopathology data found for Lpp.

IMPC related publications

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External links

No external links available for Lpp.

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*Lpp^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Lpp^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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