Adamts16 | ADAM metallopeptidase with thrombospondin type 1 motif 16
GeneMGI:2429637
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Hematopoietic system Behavior/neurological Skeleton
11 No significant impact
7 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased bone mineral content | 2 supporting datasets | Adamts16em1(IMPC)H | homozygote | Early adult | 8.28x10-8 | ||
| decreased circulating potassium level | 1 supporting dataset | Adamts16em1(IMPC)H | homozygote | Early adult | 2.64x10-5 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Adamts16em1(IMPC)H | homozygote | Early adult | 3.36x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Adamts16em1(IMPC)H | homozygote | Early adult | 2.29x10-5 | ||
| decreased eosinophil cell number | 2 supporting datasets | Adamts16em1(IMPC)H | homozygote | Early adult | 5.12x10-5 | ||
| decreased neutrophil cell number | 1 supporting dataset | Adamts16em1(IMPC)H | homozygote | Early adult | 2.85x10-5 | ||
| tremors | 1 supporting dataset | Adamts16em1(IMPC)H | homozygote | Early adult | 4.81x10-6 |
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Human diseases caused by Adamts16 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Adamts16.
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| Adamts16em1(IMPC)H | Exon Deletion | | mouse |
| Adamts16em1(IMPC)J | Exon Deletion | | mouse |
| Adamts16em2(IMPC)H | Exon Deletion | | mouse |
| Adamts16tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Adamts16tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Adamts16tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Adamts16tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Adamts16tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Adamts16tm40100(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |