Nod2 | nucleotide-binding oligomerization domain containing 2

GeneMGI:2429397Synonyms: Nlrc2, F830032C23Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Reproductive system Immune system Endocrine/exocrine gland Behavior/neurological

16 No significant impact

4 Not tested

Gene metrics:8Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal testis morphology1 supporting datasetNod2em1(IMPC)MbphomozygoteEarly adultN/A * 
decreased thigmotaxis1 supporting datasetNod2em1(IMPC)MbphomozygoteEarly adult1.16x10-5 
enlarged lymph nodes1 supporting datasetNod2em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal behavior1 supporting datasetNod2em1(IMPC)MbphomozygoteEarly adult1.21x10-5 
abnormal pancreas morphology1 supporting datasetNod2em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal lymph node morphology1 supporting datasetNod2em1(IMPC)MbphomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Nod2em1(IMPC)MbpExon Deletionmouse
Nod2tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Nod2tm47893(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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