Brcc3 | BRCA1/BRCA2-containing complex, subunit 3

GeneMGI:2389572Synonyms: C6.1A

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Immune system Hematopoietic system

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased eosinophil cell number	2 supporting datasets	Brcc3^{em1(IMPC)Marc}	homozygote	Early adult	5.22x10^-13
increased mean corpuscular volume	1 supporting dataset	Brcc3^{em1(IMPC)Marc}	homozygote	Early adult	7.2x10^-13
thrombocytosis	1 supporting dataset	Brcc3^{em1(IMPC)Wtsi}	homozygote	Early adult	8.7x10^-7
thrombocytosis	1 supporting dataset	Brcc3^{em1(IMPC)Marc}	homozygote	Early adult	7.71x10^-7
increased mean corpuscular hemoglobin	1 supporting dataset	Brcc3^{em1(IMPC)Marc}	homozygote	Early adult	2.92x10^-8
increased mean platelet volume	1 supporting dataset	Brcc3^{em1(IMPC)Marc}	homozygote	Early adult	5.92x10^-7
increased basophil cell number	1 supporting dataset	Brcc3^{em1(IMPC)Marc}	homozygote	Early adult	1.42x10^-14

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Brcc3.

Associated images

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Histopathology

There is no histopathology data found for Brcc3.

IMPC related publications

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External links

No external links available for Brcc3.

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*Brcc3^{em1(IMPC)Marc}*	Deletion	‌	mouse
*Brcc3^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Brcc3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Brcc3^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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