Cxcl17 | C-X-C motif chemokine ligand 17

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Pigmentation Integument Hematopoietic system Renal/urinary system

15 No significant impact

3 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

enlarged uterus1 supporting datasetCxcl17tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal coat/hair pigmentation3 supporting datasetsCxcl17tm1b(EUCOMM)WtsihomozygoteEarly adult6.77x10-5 
increased mean platelet volume1 supporting datasetCxcl17tm1b(EUCOMM)WtsihomozygoteEarly adult1.12x10-5 
abnormal skin morphology1 supporting datasetCxcl17tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal uterus morphology1 supporting datasetCxcl17tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased circulating alanine transaminase level1 supporting datasetCxcl17tm1b(EUCOMM)WtsihomozygoteEarly adult6.91x10-5 
abnormal kidney morphology1 supporting datasetCxcl17tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cxcl17tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cxcl17tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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