Erlin1 | ER lipid raft associated 1

GeneMGI:2387613Synonyms: Spfh1, Keo4, +1 more

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Vision/eye Liver/biliary system Hematopoietic system Skeleton Renal/urinary system

9 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



enlarged lymph nodes	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal skin morphology	2 supporting datasets	Erlin1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal stomach morphology	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
decreased lean body mass	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Early adult	1.04x10^-5
abnormal eye morphology	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
decreased bone mineral density	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Late adult	3.77x10^-7
abnormal liver morphology	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Erlin1^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Erlin1.

Associated images

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Histopathology

There is no histopathology data found for Erlin1.

IMPC related publications

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External links

No external links available for Erlin1.

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*Erlin1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Erlin1^{tm79023(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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