Ano2 | anoctamin 2

GeneMGI:2387214Synonyms: Tmem16b

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Immune system Endocrine/exocrine gland Hematopoietic system Behavior/neurological

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

hyperactivity7 supporting datasetsAno2em1(IMPC)CcpczhomozygoteEarly adult4.42x10-7 
enlarged thymus1 supporting datasetAno2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal thymus morphology1 supporting datasetAno2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal behavior1 supporting datasetAno2em1(IMPC)CcpczhomozygoteEarly adult9.68x10-6 
decreased thigmotaxis2 supporting datasetsAno2em1(IMPC)CcpczhomozygoteEarly adult9.68x10-6 
decreased anxiety-related response1 supporting datasetAno2em1(IMPC)CcpczhomozygoteEarly adult7.84x10-8 
enlarged lymph nodes1 supporting datasetAno2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
abnormal lymph node morphology1 supporting datasetAno2em1(IMPC)CcpczhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ano2em1(IMPC)CcpczExon Deletionmouse
Ano2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ano2tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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