Ppat | phosphoribosyl pyrophosphate amidotransferase
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Vision/eye Hematopoietic system Skeleton Mortality/aging
14 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Ppatem1(IMPC)Tcp | heterozygote | Early adult | 2.3x10-5 | ||
| cataract | 1 supporting dataset | Ppatem1(IMPC)Tcp | heterozygote | Early adult | 3.61x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Ppatem1(IMPC)Tcp | heterozygote | Early adult | 7.81x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ppatem1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| abnormal cornea morphology | 1 supporting dataset | Ppatem1(IMPC)Tcp | heterozygote | Early adult | 3.15x10-5 | ||
| abnormal retina morphology | 1 supporting dataset | Ppatem1(IMPC)Tcp | heterozygote | Early adult | 6.26x10-5 | ||
| abnormal sternum morphology | 1 supporting dataset | Ppatem1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| decreased hematocrit | 1 supporting dataset | Ppatem1(IMPC)Tcp | heterozygote | Early adult | 5.36x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Ppatem1(IMPC)Tcp | homozygote | E9.5 | N/A * |
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External links
No external links available for Ppat.
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| Ppatem1(IMPC)Tcp | Exon Deletion | | mouse |
| Ppattm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ppattm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |