Dkk4 | dickkopf WNT signaling pathway inhibitor 4

GeneMGI:2385299

Physiological systems

21 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Growth/size/body region Cardiovascular system Mortality/aging

18 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



preweaning lethality, incomplete penetrance	1 supporting dataset	Dkk4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Dkk4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
enlarged heart	1 supporting dataset	Dkk4^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dkk4.

Associated images

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Histopathology

There is no histopathology data found for Dkk4.

IMPC related publications

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External links

No external links available for Dkk4.

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*Dkk4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Dkk4^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Dkk4^{tm278512(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes