Gnl2 | guanine nucleotide binding protein nucleolar 2

GeneMGI:2385207Synonyms: Ngp-1

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Respiratory system Hematopoietic system Mortality/aging

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating serum albumin level	1 supporting dataset	Gnl2^{em1(IMPC)Ccpcz}	heterozygote	Early adult	7.24x10^-5
enlarged lymph nodes	1 supporting dataset	Gnl2^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Gnl2^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Gnl2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased lung elastance	1 supporting dataset	Gnl2^{em1(IMPC)Ccpcz}	heterozygote	Early adult	7.34x10^-6
enlarged spleen	1 supporting dataset	Gnl2^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Gnl2^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gnl2.

Associated images

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Histopathology

There is no histopathology data found for Gnl2.

IMPC related publications

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External links

No external links available for Gnl2.

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*Gnl2^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Gnl2^{tm492(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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