Aph1a | aph1 homolog A, gamma secretase subunit

GeneMGI:2385110Synonyms: 6530402N02Rik

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Integument Embryo Growth/size/body region Vision/eye Behavior/neurological Skeleton Mortality/aging

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



pallor	1 supporting dataset	Aph1a^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*
abnormal skin coloration	1 supporting dataset	Aph1a^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.54x10^-5
abnormal embryo size	1 supporting dataset	Aph1a^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*
hyperactivity	4 supporting datasets	Aph1a^{tm1b(KOMP)Mbp}	heterozygote	Early adult	1.67x10^-7
pale yolk sac	1 supporting dataset	Aph1a^{tm1b(KOMP)Mbp}	homozygote	E9.5	N/A ^*
decreased total retina thickness	2 supporting datasets	Aph1a^{tm1b(KOMP)Mbp}	heterozygote	Early adult	5.95x10^-7
abnormal coat appearance	2 supporting datasets	Aph1a^{tm1b(KOMP)Mbp}	heterozygote	Early adult	2.21x10^-9
preweaning lethality, complete penetrance	3 supporting datasets	Aph1a^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Aph1a^{tm1b(KOMP)Mbp}	homozygote	E12.5	N/A ^*
increased bone mineral content	1 supporting dataset	Aph1a^{tm1b(KOMP)Mbp}	heterozygote	Early adult	7.26x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aph1a.

Associated images

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Histopathology

There is no histopathology data found for Aph1a.

IMPC related publications

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External links

No external links available for Aph1a.

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*Aph1a^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Aph1a^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Aph1a^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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