L2hgdh | L-2-hydroxyglutarate dehydrogenase

GeneMGI:2384968

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Reproductive system Vision/eye Behavior/neurological

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal eye morphology	1 supporting dataset	L2hgdh^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
male infertility	1 supporting dataset	L2hgdh^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	L2hgdh^em1(IMPC)Tcp	homozygote	Early adult	1.35x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for L2hgdh.

Associated images

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Histopathology

There is no histopathology data found for L2hgdh.

IMPC related publications

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External links

No external links available for L2hgdh.

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*L2hgdh^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*L2hgdh^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*L2hgdh^{tm85376(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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