Wrap53 | WD repeat containing, antisense to Trp53

GeneMGI:2384933Synonyms: Wdr79

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Cardiovascular system Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased circulating LDL cholesterol level	1 supporting dataset	Wrap53^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.77x10^-5
decreased circulating cholesterol level	1 supporting dataset	Wrap53^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.58x10^-6
increased lean body mass	1 supporting dataset	Wrap53^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.91x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Wrap53^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased circulating fructosamine level	1 supporting dataset	Wrap53^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.59x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Wrap53^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.95x10^-5
prenatal lethality prior to heart atrial septation	1 supporting dataset	Wrap53^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*
increased heart weight	1 supporting dataset	Wrap53^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.98x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wrap53.

Associated images

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Histopathology

There is no histopathology data found for Wrap53.

IMPC related publications

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External links

No external links available for Wrap53.

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*Wrap53^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Wrap53^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Wrap53^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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