Tmem51 | transmembrane protein 51

GeneMGI:2384874

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Hearing/vestibular/ear Vision/eye Behavior/neurological

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased prepulse inhibition	3 supporting datasets	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.24x10^-9
abnormal auditory brainstem response	5 supporting datasets	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.23x10^-6
abnormal gait	1 supporting dataset	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	7.88x10^-6
abnormal startle reflex	1 supporting dataset	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.55x10^-17
abnormal startle reflex	1 supporting dataset	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	1.49x10^-11
abnormal startle reflex	1 supporting dataset	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Middle aged adult	5.04x10^-7
decreased startle reflex	1 supporting dataset	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.39x10^-7
decreased circulating fructosamine level	1 supporting dataset	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.1x10^-5
abnormal retina morphology	1 supporting dataset	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	3.33x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Tmem51^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.51x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmem51.

Associated images

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Histopathology

There is no histopathology data found for Tmem51.

IMPC related publications

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External links

No external links available for Tmem51.

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*Tmem51^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tmem51^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tmem51^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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