Ap1ar | adaptor-related protein complex 1 associated regulatory protein

GeneMGI:2384822Synonyms: Gadkin

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Integument Growth/size/body region Vision/eye Skeleton Cardiovascular system

13 No significant impact

6 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues

Phenotypes

decreased total retina thickness2 supporting datasetsAp1artm2b(EUCOMM)HmguhomozygoteEarly adult3x10-10 
increased bone mineral content1 supporting datasetAp1artm2b(EUCOMM)HmguhomozygoteEarly adult2.48x10-5 
increased lean body mass2 supporting datasetsAp1artm2b(EUCOMM)HmguhomozygoteEarly adult2.34x10-7 
abnormal retina inner nuclear layer morphology1 supporting datasetAp1artm2b(EUCOMM)HmguhomozygoteEarly adult3.69x10-5 
increased heart weight1 supporting datasetAp1artm2b(EUCOMM)HmguhomozygoteEarly adult1.11x10-8 
abnormal coat appearance2 supporting datasetsAp1artm2b(EUCOMM)HmguhomozygoteEarly adult6.8x10-13 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ap1artm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Ap1artm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Ap1artm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ap1artm2b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse

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