Eif4g1 | eukaryotic translation initiation factor 4, gamma 1

GeneMGI:2384784Synonyms: E030015G23Rik

Physiological systems

20 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging Cardiovascular system

10 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:13Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased lean body mass2 supporting datasetsEif4g1em1(IMPC)HmguheterozygoteEarly adult2.83x10-5 
abnormal retina blood vessel morphology1 supporting datasetEif4g1em1(IMPC)HmguheterozygoteEarly adult3.79x10-19 
decreased spleen weight1 supporting datasetEif4g1em1(IMPC)HmguheterozygoteEarly adult1.97x10-5 
increased circulating aspartate transaminase level1 supporting datasetEif4g1em1(IMPC)HmguheterozygoteEarly adult2.53x10-11 
increased total body fat amount2 supporting datasetsEif4g1em1(IMPC)HmguheterozygoteEarly adult3.05x10-6 
abnormal retina vasculature morphology1 supporting datasetEif4g1em1(IMPC)HmguheterozygoteEarly adult1.52x10-17 
increased total retina thickness1 supporting datasetEif4g1em1(IMPC)HmguheterozygoteEarly adult6.23x10-5 
preweaning lethality, complete penetrance1 supporting datasetEif4g1em1(IMPC)HmguhomozygoteEarly adultN/A * 
increased fasting circulating glucose level1 supporting datasetEif4g1em1(IMPC)HmguheterozygoteEarly adult5.64x10-5 
decreased bone mineral density1 supporting datasetEif4g1em1(IMPC)HmguheterozygoteEarly adult2.84x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Eif4g1em1(IMPC)HmguExon Deletionmouse
Eif4g1tm43513(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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