Herc1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Physiological systems
18 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Hearing/vestibular/ear Vision/eye Hematopoietic system Skeleton
9 No significant impact
6 Not tested
Data collections
Gene metrics:24Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased monocyte cell number | 2 supporting datasets | Herc1em3(IMPC)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal auditory brainstem response | 1 supporting dataset | Herc1em3(IMPC)Wtsi | homozygote | Early adult | 1.31x10-6 | ||
| increased total body fat amount | 2 supporting datasets | Herc1em3(IMPC)Wtsi | homozygote | Early adult | 1.33x10-15 | ||
| decreased bone mineral content | 2 supporting datasets | Herc1em3(IMPC)Wtsi | homozygote | Early adult | 3.8x10-12 | ||
| increased circulating sodium level | 1 supporting dataset | Herc1em3(IMPC)Wtsi | homozygote | Early adult | 6.14x10-14 | ||
| increased leukocyte cell number | 2 supporting datasets | Herc1em3(IMPC)Wtsi | homozygote | Early adult | 7.35x10-6 | ||
| increased mean platelet volume | 2 supporting datasets | Herc1em3(IMPC)Wtsi | homozygote | Early adult | 1.51x10-9 | ||
| decreased lean body mass | 2 supporting datasets | Herc1em3(IMPC)Wtsi | homozygote | Early adult | 1.87x10-12 | ||
| male infertility | 1 supporting dataset | Herc1em3(IMPC)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Herc1em3(IMPC)Wtsi | homozygote | Early adult | 7.45x10-6 |
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External links
No external links available for Herc1.
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