Alkbh1 | alkB homolog 1, histone H2A dioxygenase

GeneMGI:2384034Synonyms: Alkbh, Nrp, +1 more

Physiological systems

23 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Immune system Integument Endocrine/exocrine gland Digestive/alimentary Liver/biliary system Hematopoietic system Mortality/aging Renal/urinary system

15 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged lymph nodes	2 supporting datasets	Alkbh1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
abnormal ileum morphology	1 supporting dataset	Alkbh1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Alkbh1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Alkbh1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Alkbh1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Alkbh1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
abnormal vibrissa morphology	1 supporting dataset	Alkbh1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	8.93x10^-5
abnormal mammary gland morphology	1 supporting dataset	Alkbh1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	N/A ^*
abnormal defecation	1 supporting dataset	Alkbh1^{tm1b(EUCOMM)Hmgu}	heterozygote	Late adult	9.32x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Alkbh1.

Associated images

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Histopathology

There is no histopathology data found for Alkbh1.

IMPC related publications

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External links

No external links available for Alkbh1.

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*Alkbh1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Alkbh1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Alkbh1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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