Pkhd1l1 | polycystic kidney and hepatic disease 1-like 1

GeneMGI:2183153Synonyms: D86 mRNA, PKHDL1, +1 more

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Immune system Hematopoietic system

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased red blood cell distribution width1 supporting datasetPkhd1l1em1(IMPC)HhomozygoteEarly adult4.7x10-11 
increased neutrophil cell number2 supporting datasetsPkhd1l1em1(IMPC)HhomozygoteEarly adult8.54x10-9 
increased leukocyte cell number1 supporting datasetPkhd1l1em1(IMPC)HhomozygoteEarly adult8.53x10-5 
increased monocyte cell number1 supporting datasetPkhd1l1em1(IMPC)HhomozygoteEarly adult2.62x10-8 
decreased lymphocyte cell number1 supporting datasetPkhd1l1em1(IMPC)HhomozygoteEarly adult1.61x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pkhd1l1em1(IMPC)HExon Deletionmouse
Pkhd1l1em2(IMPC)HExon Deletionmouse
Pkhd1l1tm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Pkhd1l1tm2e(EUCOMM)HmguTargeted, non-conditional allelees cell

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