Hps5 | HPS5, biogenesis of lysosomal organelles complex 2 subunit 2

GeneMGI:2180307Synonyms: ruby eye 2, ru-2, +2 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Pigmentation Integument Vision/eye Behavior/neurological

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal coat/hair pigmentation	5 supporting datasets	Hps5^em1(IMPC)J	homozygote	Early adult	1.97x10^-9
abnormal iris transillumination	1 supporting dataset	Hps5^em1(IMPC)J	homozygote	Early adult	1.19x10^-5
abnormal iris pigmentation	1 supporting dataset	Hps5^em1(IMPC)J	homozygote	Early adult	4.07x10^-21
hyperactivity	4 supporting datasets	Hps5^em1(IMPC)J	homozygote	Early adult	3.17x10^-5
increased vertical activity	1 supporting dataset	Hps5^em1(IMPC)J	homozygote	Early adult	9.67x10^-5
abnormal behavior	2 supporting datasets	Hps5^em1(IMPC)J	homozygote	Early adult	2.76x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hps5.

Associated images

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Histopathology

There is no histopathology data found for Hps5.

IMPC related publications

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External links

No external links available for Hps5.

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*Hps5^em1(IMPC)J*	Exon Deletion	‌	mouse
*Hps5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Hps5^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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