Mvd | mevalonate (diphospho) decarboxylase

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Pigmentation Integument Behavior/neurological Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat/hair pigmentation1 supporting datasetMvdem1(IMPC)JheterozygoteEarly adult1.84x10-6 
abnormal vocalization1 supporting datasetMvdem1(IMPC)JheterozygoteEarly adult1.46x10-5 
embryonic lethality prior to organogenesis1 supporting datasetMvdem1(IMPC)JhomozygoteE9.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetMvdem1(IMPC)JhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mvdem1(IMPC)JExon Deletionmouse
Mvdtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Mvdtm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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