Bloc1s5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted

GeneMGI:2178598Synonyms: 1810074A19Rik, Muted, +2 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Pigmentation Integument Endocrine/exocrine gland Vision/eye Mortality/aging Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



preweaning lethality, incomplete penetrance	2 supporting datasets	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal skin coloration	1 supporting dataset	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	1.1x10^-8
abnormal iris pigmentation	1 supporting dataset	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	1.57x10^-8
abnormal coat/hair pigmentation	3 supporting datasets	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	1.1x10^-8
abnormal seminal vesicle morphology	1 supporting dataset	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal iris morphology	1 supporting dataset	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	1.71x10^-7
abnormal skin morphology	1 supporting dataset	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal retina blood vessel morphology	1 supporting dataset	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	1.61x10^-8
abnormal retina morphology	1 supporting dataset	Bloc1s5^em1(IMPC)Tcp	homozygote	Early adult	2.74x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Bloc1s5.

Associated images

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Histopathology

There is no histopathology data found for Bloc1s5.

IMPC related publications

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External links

No external links available for Bloc1s5.

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*Bloc1s5^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Bloc1s5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Bloc1s5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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