Vps37d | vacuolar protein sorting 37D

GeneMGI:2159402Synonyms: Wbscr24

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

1Associated diseases

Expression examined in:49Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



unresponsive to tactile stimuli	1 supporting dataset	Vps37d^{tm2b(EUCOMM)Wtsi}	heterozygote	E18.5	N/A ^*
decreased prepulse inhibition	2 supporting datasets	Vps37d^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	4.85x10^-13
decreased total retina thickness	2 supporting datasets	Vps37d^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	2.57x10^-20
unresponsive to tactile stimuli	1 supporting dataset	Vps37d^{tm2b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
decreased locomotor activity	2 supporting datasets	Vps37d^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	1.71x10^-5
abnormal retina inner nuclear layer morphology	2 supporting datasets	Vps37d^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	5.11x10^-20
abnormal body wall morphology	1 supporting dataset	Vps37d^{tm2b(EUCOMM)Wtsi}	homozygote	E18.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Vps37d^{tm2b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Vps37d.

Associated images

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Histopathology

There is no histopathology data found for Vps37d.

IMPC related publications

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External links

No external links available for Vps37d.

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*Vps37d^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Vps37d^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Vps37d^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Vps37d^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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