Tmie | transmembrane inner ear

GeneMGI:2159400Synonyms: 5131400L21Rik, Mm.87012

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Pigmentation Integument Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal vocalization1 supporting datasetTmieem1(IMPC)JheterozygoteEarly adult2.42x10-10 
abnormal coat/hair pigmentation1 supporting datasetTmieem1(IMPC)JheterozygoteEarly adult4.2x10-12 
abnormal behavior1 supporting datasetTmieem1(IMPC)JhomozygoteEarly adult5.63x10-7 
abnormal startle reflex1 supporting datasetTmieem1(IMPC)JhomozygoteEarly adult1.58x10-5 
increased aggression1 supporting datasetTmieem1(IMPC)JhomozygoteEarly adult5.12x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetTmieem1(IMPC)JhomozygoteEarly adultN/A * 
head bobbing1 supporting datasetTmieem1(IMPC)JhomozygoteEarly adult5.63x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tmieem1(IMPC)JExon Deletionmouse
Tmietm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Tmietm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Tmietm429560(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Tmietm429560(L1L2_GT0_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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