Asic3 | acid-sensing ion channel 3

GeneMGI:2159339Synonyms: Accn3, DRASIC

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Growth/size/body region Nervous system Hearing/vestibular/ear Liver/biliary system Hematopoietic system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	1 supporting dataset	Asic3^em1(IMPC)Mbp	homozygote	Early adult	2.88x10^-6
abnormal liver morphology	1 supporting dataset	Asic3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small liver	1 supporting dataset	Asic3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Asic3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Asic3^em1(IMPC)Mbp	homozygote	Early adult	1.02x10^-7
decreased prepulse inhibition	3 supporting datasets	Asic3^em1(IMPC)Mbp	homozygote	Early adult	4.86x10^-7
enlarged gallbladder	1 supporting dataset	Asic3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Asic3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal gallbladder morphology	1 supporting dataset	Asic3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Asic3.

Associated images

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Histopathology

There is no histopathology data found for Asic3.

IMPC related publications

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External links

No external links available for Asic3.

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*Asic3^em1(IMPC)Mbp*	Intra-exon deletion	‌	mouse
*Asic3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Asic3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Asic3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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