Cln6 | ceroid-lipofuscinosis, neuronal 6

GeneMGI:2159324Synonyms: 1810065L06Rik, D9Bwg1455e

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Adipose tissue Growth/size/body region Nervous system Vision/eye Cardiovascular system

12 No significant impact

7 Not tested

Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased prepulse inhibition2 supporting datasetsCln6tm1b(EUCOMM)HmguhomozygoteEarly adult4.36x10-7 
abnormal retina morphology1 supporting datasetCln6tm1b(EUCOMM)HmguhomozygoteEarly adult6.86x10-13 
increased heart weight1 supporting datasetCln6tm1b(EUCOMM)HmguhomozygoteEarly adult6.57x10-5 
decreased total body fat amount1 supporting datasetCln6tm1b(EUCOMM)HmguhomozygoteEarly adult2.97x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Cln6tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Cln6tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Cln6tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Cln6tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Cln6tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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