Mlc1 | megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

GeneMGI:2157910Synonyms: Kiaa0027-hp, WKL1

Physiological systems

21 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Reproductive system Nervous system

19 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased brain weight	1 supporting dataset	Mlc1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.55x10^-13
abnormal uterus morphology	1 supporting dataset	Mlc1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mlc1.

Associated images

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Histopathology

There is no histopathology data found for Mlc1.

IMPC related publications

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External links

No external links available for Mlc1.

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*Mlc1^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Mlc1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Mlc1^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Mlc1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Mlc1^{tm447806(L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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