Elovl6 | ELOVL fatty acid elongase 6

GeneMGI:2156528Synonyms: LCE, FEN1/Elo2, SUR4/Elo3-like, +1 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased red blood cell distribution width	1 supporting dataset	Elovl6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.5x10^-6
increased circulating triglyceride level	1 supporting dataset	Elovl6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.06x10^-7
limb grasping	1 supporting dataset	Elovl6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.3x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Elovl6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.95x10^-6
increased circulating amylase level	1 supporting dataset	Elovl6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.04x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Elovl6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Elovl6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.26x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Elovl6.

Associated images

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Histopathology

There is no histopathology data found for Elovl6.

IMPC related publications

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External links

No external links available for Elovl6.

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*Elovl6^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Elovl6^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Elovl6^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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