Sec63 | SEC63 homolog, protein translocation regulator

GeneMGI:2155302Synonyms: 5730478J10Rik

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Hematopoietic system Skeleton Mortality/aging

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

2Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to organogenesis	1 supporting dataset	Sec63^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Sec63^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.59x10^-5
increased neutrophil cell number	2 supporting datasets	Sec63^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3x10^-7
decreased lymphocyte cell number	1 supporting dataset	Sec63^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.95x10^-6
embryonic lethality prior to tooth bud stage	1 supporting dataset	Sec63^{tm1b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
decreased bone mineral density	1 supporting dataset	Sec63^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.99x10^-5
abnormal vibrissa morphology	1 supporting dataset	Sec63^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.02x10^-8
preweaning lethality, complete penetrance	1 supporting dataset	Sec63^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
absent vibrissae	1 supporting dataset	Sec63^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.24x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sec63.

Associated images

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Histopathology

There is no histopathology data found for Sec63.

IMPC related publications

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External links

No external links available for Sec63.

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*Sec63^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sec63^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sec63^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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