Sesn1 | sestrin 1

GeneMGI:2155278Synonyms: 1110002G11Rik, SEST1, +1 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Nervous system Vision/eye Hematopoietic system Behavior/neurological

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular hemoglobin	1 supporting dataset	Sesn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	3.13x10^-5
abnormal optic disk morphology	1 supporting dataset	Sesn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.29x10^-7
increased aggression	1 supporting dataset	Sesn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.39x10^-5
increased mean corpuscular volume	1 supporting dataset	Sesn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.33x10^-5
persistence of hyaloid vascular system	1 supporting dataset	Sesn1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.02x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sesn1.

Associated images

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Histopathology

There is no histopathology data found for Sesn1.

IMPC related publications

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External links

No external links available for Sesn1.

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*Sesn1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sesn1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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