Rxfp2 | relaxin/insulin-like family peptide receptor 2

GeneMGI:2153463Synonyms: Great, LGR8, +1 more

Physiological systems

23 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Nervous system Vision/eye Respiratory system Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

12 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased circulating lipase level	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	9.44x10^-7
abnormal liver morphology	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
prolonged QT interval	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.35x10^-7
small testis	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.34x10^-5
abnormal optic disk morphology	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.17x10^-6
urinary bladder obstruction	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
male infertility	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased erythrocyte cell number	1 supporting dataset	Rxfp2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	4.01x10^-6
decreased locomotor activity	1 supporting dataset	Rxfp2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.18x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rxfp2.

Associated images

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Histopathology

There is no histopathology data found for Rxfp2.

IMPC related publications

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External links

No external links available for Rxfp2.

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*Rxfp2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Rxfp2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rxfp2^{tm39993(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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