Mta1 | metastasis associated 1

Physiological systems

23 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Adipose tissue Growth/size/body region Limbs/digits/tail Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Mortality/aging

12 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



abnormal behavior	4 supporting datasets	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.07x10^-10
decreased lumbar vertebrae number	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.77x10^-6
increased total body fat amount	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.03x10^-8
decreased caudal vertebrae number	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.57x10^-7
decreased bone mineral density	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.11x10^-5
abnormal rib morphology	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.03x10^-5
decreased sacral vertebrae number	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.77x10^-6
decreased mean corpuscular volume	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.8x10^-5
decreased lean body mass	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.94x10^-5
decreased caudal vertebrae number	1 supporting dataset	Mta1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.65x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mta1.

Associated images

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Histopathology

There is no histopathology data found for Mta1.

IMPC related publications

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External links

No external links available for Mta1.

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*Mta1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Mta1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mta1^{tm39847(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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