Hycc1 | hyccin PI4KA lipid kinase complex subunit 1

GeneMGI:2149839Synonyms: Fam126a, hyccin

Physiological systems

23 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Endocrine/exocrine gland Digestive/alimentary Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system

15 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



dilated heart left ventricle	4 supporting datasets	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.53x10^-6
enlarged thymus	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.55x10^-5
decreased circulating total protein level	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.41x10^-5
increased fasting circulating glucose level	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.73x10^-12
increased cardiac stroke volume	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.42x10^-5
increased circulating potassium level	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.45x10^-7
increased monocyte cell number	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.14x10^-5
abnormal inspiratory capacity	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.44x10^-6
abnormal salivary gland morphology	1 supporting dataset	Hycc1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hycc1.

Associated images

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Histopathology

There is no histopathology data found for Hycc1.

IMPC related publications

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External links

No external links available for Hycc1.

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*Hycc1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Hycc1^{tm40799(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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