Afap1l2 | actin filament associated protein 1-like 2

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Adipose tissue Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	1 supporting dataset	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	6.04x10^-6
abnormal spleen morphology	1 supporting dataset	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral content	2 supporting datasets	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.64x10^-6
increased neutrophil cell number	1 supporting dataset	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.75x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.06x10^-7
decreased total body fat amount	1 supporting dataset	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.58x10^-6
increased startle reflex	1 supporting dataset	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.69x10^-5
improved glucose tolerance	2 supporting datasets	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.38x10^-10
prolonged RR interval	1 supporting dataset	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.55x10^-6
decreased heart rate	1 supporting dataset	Afap1l2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.12x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Afap1l2.

Associated images

Loading...

Histopathology

There is no histopathology data found for Afap1l2.

IMPC related publications

Loading...

External links

No external links available for Afap1l2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Afap1l2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Afap1l2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Afap1l2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes