Scrib | scribbled planar cell polarity

GeneMGI:2145950Synonyms: Crc, Scrb1

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging Cardiovascular system Craniofacial

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Scrib^{tm1b(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	homozygote	E12.5	N/A ^*
abnormal retina morphology	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	heterozygote	Early adult	5.66x10^-7
abnormal neural tube closure	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	homozygote	E9.5	N/A ^*
abnormal midbrain morphology	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	homozygote	E12.5	N/A ^*
abnormal gait	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	heterozygote	Early adult	8.3x10^-5
abnormal hindbrain morphology	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	homozygote	E12.5	N/A ^*
pale yolk sac	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	homozygote	E12.5	N/A ^*
abnormal eye morphology	1 supporting dataset	Scrib^{tm1b(NCOM)Mfgc}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Scrib.

Associated images

Loading...

Histopathology

There is no histopathology data found for Scrib.

IMPC related publications

Loading...

External links

No external links available for Scrib.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Scrib^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Scrib^{tm1a(NCOM)Mfgc}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Scrib^{tm1b(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

My Genes