Brd9 | bromodomain containing 9

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Hematopoietic system Skeleton Mortality/aging Renal/urinary system

11 No significant impact

3 Not tested

Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal skin morphology1 supporting datasetBrd9em1(IMPC)TcpheterozygoteEarly adultN/A * 
abnormal seminal vesicle morphology1 supporting datasetBrd9em1(IMPC)TcpheterozygoteLate adultN/A * 
preweaning lethality, complete penetrance3 supporting datasetsBrd9em1(IMPC)TcphomozygoteEarly adultN/A * 
small adrenal glands1 supporting datasetBrd9em1(IMPC)TcpheterozygoteLate adultN/A * 
enlarged urinary bladder1 supporting datasetBrd9em1(IMPC)TcpheterozygoteLate adultN/A * 
decreased bone mineral content1 supporting datasetBrd9em1(IMPC)TcpheterozygoteLate adult4.85x10-5 
increased circulating HDL cholesterol level1 supporting datasetBrd9em1(IMPC)TcpheterozygoteEarly adult9.53x10-5 
small uterus1 supporting datasetBrd9em1(IMPC)TcpheterozygoteLate adultN/A * 
increased neutrophil cell number1 supporting datasetBrd9em1(IMPC)TcpheterozygoteEarly adult2.87x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Brd9em1(IMPC)TcpExon Deletionmouse
Brd9tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Brd9tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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