Txndc5 | thioredoxin domain containing 5

GeneMGI:2145316Synonyms: ERp46, PC-TRP

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Behavior/neurological

17 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



hyperactivity	5 supporting datasets	Txndc5^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.08x10^-6
decreased circulating cholesterol level	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	7.9x10^-7
small testis	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
decreased circulating triglyceride level	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.93x10^-5
small testis	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small seminal vesicle	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
decreased circulating serum albumin level	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.93x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
increased circulating insulin level	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.9x10^-13
abnormal testis morphology	1 supporting dataset	Txndc5^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Txndc5.

Associated images

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Histopathology

There is no histopathology data found for Txndc5.

IMPC related publications

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External links

No external links available for Txndc5.

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*Txndc5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Txndc5^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Txndc5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Txndc5^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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