Ptpn23 | protein tyrosine phosphatase, non-receptor type 23

GeneMGI:2144837Synonyms: PTP-TD14

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating HDL cholesterol level	1 supporting dataset	Ptpn23^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.26x10^-8
increased circulating alkaline phosphatase level	1 supporting dataset	Ptpn23^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.28x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Ptpn23^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating cholesterol level	1 supporting dataset	Ptpn23^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.39x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ptpn23.

Associated images

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Histopathology

There is no histopathology data found for Ptpn23.

IMPC related publications

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External links

No external links available for Ptpn23.

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*Ptpn23^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Ptpn23^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ptpn23^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ptpn23^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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