Ppp4r3b | protein phosphatase 4 regulatory subunit 3B

GeneMGI:2144474Synonyms: Smek2

Physiological systems

23 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

12 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal liver morphology	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
enlarged uterus	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
increased total retina thickness	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.8x10^-7
abnormal kidney morphology	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
abnormal ovary morphology	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
decreased bone mineral density	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	2.13x10^-5
impaired glucose tolerance	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.83x10^-5
abnormal gait	1 supporting dataset	Ppp4r3b^{tm1b(EUCOMM)Hmgu}	homozygote	Late adult	6.75x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppp4r3b.

Associated images

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Histopathology

There is no histopathology data found for Ppp4r3b.

IMPC related publications

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External links

No external links available for Ppp4r3b.

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*Ppp4r3b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ppp4r3b^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ppp4r3b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Ppp4r3b^{tm33774(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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