Usp22 | ubiquitin specific peptidase 22

GeneMGI:2144157

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



increased lean body mass	1 supporting dataset	Usp22^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	4.83x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Usp22^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular hemoglobin	1 supporting dataset	Usp22^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.29x10^-8
preweaning lethality, complete penetrance	1 supporting dataset	Usp22^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal gait	1 supporting dataset	Usp22^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.76x10^-7
increased mean corpuscular hemoglobin concentration	1 supporting dataset	Usp22^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	6.99x10^-11
increased red blood cell distribution width	1 supporting dataset	Usp22^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.66x10^-5
increased monocyte cell number	1 supporting dataset	Usp22^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	2.58x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Usp22.

Associated images

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Histopathology

There is no histopathology data found for Usp22.

IMPC related publications

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External links

No external links available for Usp22.

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*Usp22^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Usp22^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Usp22^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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