Gls2 | glutaminase 2 (liver, mitochondrial)

GeneMGI:2143539Synonyms: A330074B06Rik, Lga

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Liver/biliary system Hematopoietic system Skeleton Renal/urinary system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



enlarged lymph nodes	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
enlarged spleen	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal sternum morphology	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*
abnormal coat/ hair morphology	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Late adult	1.49x10^-5
thrombocytosis	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Early adult	1.8x10^-5
abnormal ovary morphology	1 supporting dataset	Gls2^em1(IMPC)Tcp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gls2.

Associated images

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Histopathology

There is no histopathology data found for Gls2.

IMPC related publications

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External links

No external links available for Gls2.

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*Gls2^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Gls2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gls2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Gls2^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gls2^{tm79261(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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