Nsd3 | nuclear receptor binding SET domain protein 3

GeneMGI:2142581Synonyms: Whsc1l1, WHISTLE

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging Craniofacial

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased startle reflex	1 supporting dataset	Nsd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.6x10^-8
decreased exploration in new environment	1 supporting dataset	Nsd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.05x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Nsd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.25x10^-17
preweaning lethality, incomplete penetrance	1 supporting dataset	Nsd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Nsd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
tremors	1 supporting dataset	Nsd3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.7x10^-6
trunk curl	1 supporting dataset	Nsd3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.96x10^-9
increased total body fat amount	2 supporting datasets	Nsd3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.94x10^-6
abnormal snout morphology	1 supporting dataset	Nsd3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.72x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nsd3.

Associated images

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Histopathology

There is no histopathology data found for Nsd3.

IMPC related publications

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External links

No external links available for Nsd3.

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*Nsd3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Nsd3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Nsd3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Nsd3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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