Arhgef18 | Rho/Rac guanine nucleotide exchange factor 18

GeneMGI:2142567Synonyms: A430078G23Rik, D030053O22Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



abnormal retina morphology	1 supporting dataset	Arhgef18^{tm1b(KOMP)Mbp}	heterozygote	Early adult	1.15x10^-16
preweaning lethality, complete penetrance	1 supporting dataset	Arhgef18^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
increased circulating amylase level	1 supporting dataset	Arhgef18^{tm1b(KOMP)Mbp}	heterozygote	Early adult	8.26x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Arhgef18^{Gt(EUC0027g03)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Arhgef18.

Associated images

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Histopathology

There is no histopathology data found for Arhgef18.

IMPC related publications

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External links

No external links available for Arhgef18.

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*Arhgef18^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Arhgef18^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Arhgef18^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Arhgef18^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	es cell
*Arhgef18^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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