Unc45a | unc-45 myosin chaperone A

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Behavior/neurological Mortality/aging Cardiovascular system

15 No significant impact

6 Not tested

Gene metrics:4Significant phenotypes
1Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues

Phenotypes

prolonged RR interval1 supporting datasetUnc45atm1b(EUCOMM)HmguheterozygoteEarly adult4.21x10-5 
decreased heart rate1 supporting datasetUnc45atm1b(EUCOMM)HmguheterozygoteEarly adult4.15x10-5 
decreased exploration in new environment1 supporting datasetUnc45atm1b(EUCOMM)HmguheterozygoteEarly adult8.18x10-5 
preweaning lethality, complete penetrance1 supporting datasetUnc45atm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Unc45atm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Unc45atm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Unc45atm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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